AMCRYLATE 0.25ML INJECTION

Introduction:

DC Bead 100-300μm Injection is a drug delivery embolization system in saline. It is intended for the local treatment of cancer in the liver, colon and rectμm. This system can be loaded with anticancer drugs like Doxorubicin and Irinotecan. It is designed in such a way that the medication reaches explicitly and targets the cancer cells. This spares the associated organ and minimizes the severe side effects associated with drug use alone.

Liver cancer does not show an adequate response to radiation therapy. The response rate to chemotherapy is also only around 30%, so the embolization technique is employed. Your physician will monitor using CT or MRI scan before injecting this device into your body.

Uses of DC Bead 100-300μm Injection:

• Treatment of liver and colorectal cancers

How DC Bead 100-300μm Injection works:

DC Bead 100-300μm Injection is injected through the artery where the loaded drug molecule (Doxorubicin or Irinotecan) gets activated. The drug molecule leaves the bead, travels through the blood vessel wall through the tissue and selectively attacks and kills the cancer cells.

Interaction with other drugs:

Inform your physician regarding any medicines you are taking or have taken before the treatment.

More Information:

Store as per the labelled instructions.

References:

1. Boston Scientific Corporation, [Revised on 2020] [Accessed on 16th Aug 2021], https://www.bostonscientific.com/content/dam/bostonscientific/pi/portfolio-group/embolization/peripheral-embolisation-booklet.pdf
2. Lewis & Hall, Toward a better understanding of the mechanism of action for intra-arterial delivery of irinotecan from DC Bead(TM) (DEBIRI), Future Oncol., 2019, 15(17), 2053–2068, https://www.futuremedicine.com/doi/pdfplus/10.2217/fon-2019-0071
3. A. Hagan, et al., Predicting pharmacokinetic behaviour of drug release from drug-elutingembolization beads usingin vitroelution methods, European Journal of Pharmaceutical Sciences, 2019, https://reader.elsevier.com/reader/sd/pii/S0928098719301988?token=D4FCA85C5D133A0E2EBD19E7C1208006FAA4C8F55455A41C436F0C5E5072929909FDCBA9B2E7B560F415E2B17AA0CD3A&originRegion=eu-west-1&originCreation=20210816045851
4. Q.M. Anstee, D.E.J. Jones, Liver and biliary tract disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 921-988.
5. Malagari, Eμmanoui, Pomoni & Kelekis, Chemoembolization with DC Bead™ for the treatment of hepatocellular carcinoma: an update, Hepatic Oncol., 2014, 1(2), https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095310/pdf/hep-01-205.pdf

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